#TITLE_ALTERNATIVE#

• Main Author: PRASTIWI NIM : 11614017 , FEMILINA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/27280
• Institution: Institut Teknologi Bandung

Kidney is an important organ that has the main functions of excretion, elimination, and volume <br /> <br /> homeostasis. Kidney function abnormalities consist of acute kidney disease (AKD) and chronic <br /> <br /> kidney disease (CKD). The number of CKD patients undergoing hemodialysis therapy is always <br /> <br /> increasing from year to year. The most common comorbidities that happens in CKD patients with <br /> <br /> hemodialysis therapy are hypertension and anemia. Some drugs are used both to treat chronic <br /> <br /> kidney disease and high blood pressure or anemia that accompanies it. The use of drug needs to <br /> <br /> be considered, therefore patients get the desired therapeutic effect and avoid adverse side <br /> <br /> effects. This study was conducted to find out and evaluate the use of antihypertensive and <br /> <br /> antianemia in CKD patients with hemodialysis therapy. This study consists on analysis of the <br /> <br /> appropriateness drug use, that consist of appropriateness of indication, patient, and dosage, and <br /> <br /> also analyze potential drug interactions between antihypertensive, antianemia, or other drugs, <br /> <br /> and also analyze the decreasing of blood preasure and the increasing of hemoglobin levels in CKD <br /> <br /> patients with hemodialysis therapy in a private hospital in Bandung. The results showed that the <br /> <br /> most widely used antihypertensive was a combination of CCB-diuretic which has the percentage <br /> <br /> of 17.1%. Evaluation of the appropriateness drug use showed 82.81% appropriate indication and <br /> <br /> 78.12% appropriate patient. The use of antihypertensive showed 64.06% appropriate dose and <br /> <br /> 34.38% overdose. The use of antianemia showed 8.33% appropriate dose and 91.67% less dose. <br /> <br /> There is a potential drug interactions with moderate severity (48.31%) and major (7.86%). The <br /> <br /> highest blood pressure reduction was produced by a combination of 3 OAH both in pre-dialysis <br /> <br /> blood pressure (p= 0.006 for systolic blood pressure and p= 0.068 for diastolic blood pressure) <br /> <br /> and post-dialysis blood pressure (p= 0.015 for systolic blood pressure and p= 0.013 for diastolic <br /> <br /> blood pressure). The use of antianemia can also increase hemoglobin levels in both men (p= <br /> <br /> 0.331) and women (p= 0.057). <br />