SYNTHESIS OF ENANTIOMER BINOL-PHOSPHORIC ACID
Asymmetric catalysis is a type of catalysis in which a chiral catalyst directs the formation of a chiral <br /> <br /> compound that continue to develop today. Organocatalyst is widely used due to its easy and <br /> <br /> environmentally friendly process. For example, BINOL...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/28082 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Asymmetric catalysis is a type of catalysis in which a chiral catalyst directs the formation of a chiral <br />
<br />
compound that continue to develop today. Organocatalyst is widely used due to its easy and <br />
<br />
environmentally friendly process. For example, BINOL derived chiral phosphoric acid. The <br />
<br />
application of BINOL-phosphoric acid is used as a catalyst and resolving agent. Separation of racemic <br />
<br />
compounds from BINOL-phosphoric acid was carried out by diastereomeric salt formation and <br />
<br />
optical rotation was produced at <br />
<br />
=+2o (c=1, CHCl3) with %ee 0,3% and <br />
<br />
= -14o (c=1, <br />
<br />
CHCl3) with %ee 2%. All products was characterized by spectroscopy data including 1H-NMR and <br />
<br />
13C-NMR. |
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