#TITLE_ALTERNATIVE#
Co-crystallization is one method to modifying physicochemical properties of drugs. Diclofenac acid has <br /> <br /> known as a NSAID which has a low aqueous solubility, so it has made as salt form, such as sodium <br /> <br /> diclofenac. However, the salt form is unstable i...
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Format: | Final Project |
Language: | Indonesia |
Online Access: | https://digilib.itb.ac.id/gdl/view/28631 |
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Institution: | Institut Teknologi Bandung |
Language: | Indonesia |
Summary: | Co-crystallization is one method to modifying physicochemical properties of drugs. Diclofenac acid has <br />
<br />
known as a NSAID which has a low aqueous solubility, so it has made as salt form, such as sodium <br />
<br />
diclofenac. However, the salt form is unstable in certain pH and gastric fluid, also reduces drug <br />
<br />
absorption. Recently, some research reported that development of diclofenac-proline co-crystal using <br />
<br />
solvent-drop grinding (SDG), slow evaporation (SE), and neat grinding. The aim of this research was to <br />
<br />
find the more efficient method to develop the co-crystal and get the highest yield. Furthermore, antiinflammatory activity test performed by comparing co-crystal form of diclofenac acid with its single <br />
<br />
component using Wistar rat as the object. The selected method for recrystallization was SDG-SE using <br />
<br />
a series of the mixtures of ethanol-water, and using a new method called ͡microwave͢= The result <br />
<br />
shown that as higher ethanol concentration, the more co-crystal yielded and its size would be <br />
<br />
increased. However, cocrystal formation using SDG-SE happened much slower with less <br />
<br />
homogeneous. Meanwhile, co-crystallization method by using microwave with or without adding any <br />
<br />
solvent gave the higher yield in a shorter time. The result has been concluded based on <br />
<br />
characterization of cocrystal solid analysis data using FTIR, XRD, and DSC. The infrared specific peaks <br />
<br />
are 1681, 1905, and 3270 cm- <br />
<br />
1 <br />
<br />
; XRD on ϱשфϳ=ϱϸΦ; ϸ=϶ϲΦ; ϰϰ=ϴϳΦ; ϰϲ=ϰϷΦ; ϰϳ=ϲϰΦ; ϰϸ=ϳϱΦ; ϱϯ=ϳϷΦ; dan <br />
<br />
25.46°; and endothermic curve of DSC on 154.68°C. These data confirmed with the properties <br />
<br />
reported before. Moreover, the result of anti-inflammatory activity test showed that co-crystal form <br />
<br />
had inflammation inhibition activity stronger, then also had faster onset effect than a single form. <br />
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