#TITLE_ALTERNATIVE#

• Main Author: AYUNINGTYAS ARIA PUTRI NIM : 10714089, LIVIA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/28631
• Institution: Institut Teknologi Bandung

Co-crystallization is one method to modifying physicochemical properties of drugs. Diclofenac acid has <br /> <br /> known as a NSAID which has a low aqueous solubility, so it has made as salt form, such as sodium <br /> <br /> diclofenac. However, the salt form is unstable in certain pH and gastric fluid, also reduces drug <br /> <br /> absorption. Recently, some research reported that development of diclofenac-proline co-crystal using <br /> <br /> solvent-drop grinding (SDG), slow evaporation (SE), and neat grinding. The aim of this research was to <br /> <br /> find the more efficient method to develop the co-crystal and get the highest yield. Furthermore, antiinflammatory activity test performed by comparing co-crystal form of diclofenac acid with its single <br /> <br /> component using Wistar rat as the object. The selected method for recrystallization was SDG-SE using <br /> <br /> a series of the mixtures of ethanol-water, and using a new method called &#865;microwave&#866;= The result <br /> <br /> shown that as higher ethanol concentration, the more co-crystal yielded and its size would be <br /> <br /> increased. However, cocrystal formation using SDG-SE happened much slower with less <br /> <br /> homogeneous. Meanwhile, co-crystallization method by using microwave with or without adding any <br /> <br /> solvent gave the higher yield in a shorter time. The result has been concluded based on <br /> <br /> characterization of cocrystal solid analysis data using FTIR, XRD, and DSC. The infrared specific peaks <br /> <br /> are 1681, 1905, and 3270 cm- <br /> <br /> 1 <br /> <br /> ; XRD on &#1009;&#1513;&#1092;&#1011;=&#1009;&#1016;&#934;; &#1016;=&#1014;&#1010;&#934;; &#1008;&#1008;=&#1012;&#1011;&#934;; &#1008;&#1010;=&#1008;&#1015;&#934;; &#1008;&#1011;=&#1010;&#1008;&#934;; &#1008;&#1016;=&#1011;&#1009;&#934;; &#1009;&#1007;=&#1011;&#1015;&#934;; dan <br /> <br /> 25.46°; and endothermic curve of DSC on 154.68°C. These data confirmed with the properties <br /> <br /> reported before. Moreover, the result of anti-inflammatory activity test showed that co-crystal form <br /> <br /> had inflammation inhibition activity stronger, then also had faster onset effect than a single form. <br />