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As in the case of Active Pharmaceutical Ingredient (API), primary reference standards for national <br /> <br /> need are still supplied from import. The aim of this study was to obtain candidate of ibuprofen <br /> <br /> primary reference standards as an effort to initiate...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/28874 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | As in the case of Active Pharmaceutical Ingredient (API), primary reference standards for national <br />
<br />
need are still supplied from import. The aim of this study was to obtain candidate of ibuprofen <br />
<br />
primary reference standards as an effort to initiate national self reliance in preparing and supplying <br />
<br />
reference standards. Ibuprofen pharmaceutical grade was purified by recrystallization method in <br />
<br />
several organic solvents and the purified product was characterized using thin layer <br />
<br />
chromatography, high performance liquid chromatography, FTIR spectroscopy, nuclear magnetic <br />
<br />
resonance spectroscopy, and determination of melting point, loss on drying, residue on ignition, as <br />
<br />
well as titrimetric assay. The study showed that hexane was the most suitable solvent for ibuprofen <br />
<br />
purification. Based on overall characterization results, it was concluded that the purified ibuprofen <br />
<br />
fullfiled the purity criteria as candidate of primary reference standards and its assigned value was <br />
<br />
99,880 %. <br />
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