#TITLE_ALTERNATIVE#

• Main Author: SHARAH AYUNIN NIM : 10714038, MEUTHIA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/28874
• Institution: Institut Teknologi Bandung

As in the case of Active Pharmaceutical Ingredient (API), primary reference standards for national <br /> <br /> need are still supplied from import. The aim of this study was to obtain candidate of ibuprofen <br /> <br /> primary reference standards as an effort to initiate national self reliance in preparing and supplying <br /> <br /> reference standards. Ibuprofen pharmaceutical grade was purified by recrystallization method in <br /> <br /> several organic solvents and the purified product was characterized using thin layer <br /> <br /> chromatography, high performance liquid chromatography, FTIR spectroscopy, nuclear magnetic <br /> <br /> resonance spectroscopy, and determination of melting point, loss on drying, residue on ignition, as <br /> <br /> well as titrimetric assay. The study showed that hexane was the most suitable solvent for ibuprofen <br /> <br /> purification. Based on overall characterization results, it was concluded that the purified ibuprofen <br /> <br /> fullfiled the purity criteria as candidate of primary reference standards and its assigned value was <br /> <br /> 99,880 %. <br />