#TITLE_ALTERNATIVE#
Ciprofloxacin is a broad spectrum antibiotic that is commonly used by breeders to cure chickens with <br /> <br /> bacterial disease. Concentration of ciprofloxacin in the poultry products should be under maximum <br /> <br /> residual limit (MRL) to prevent antimicrobial res...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/29040 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Ciprofloxacin is a broad spectrum antibiotic that is commonly used by breeders to cure chickens with <br />
<br />
bacterial disease. Concentration of ciprofloxacin in the poultry products should be under maximum <br />
<br />
residual limit (MRL) to prevent antimicrobial resistance. Therefore, pharmacokinetics parameters and <br />
<br />
withdrawal time of ciprofloxacin in the poultry products should be determined. In this research, ten laying <br />
<br />
hens were given ciprofloxacin by intravenous and oral route of administration. Twelve blood samples from <br />
<br />
each laying hens were then analysed by using High Performance Liquid Chromatography with UV detector. <br />
<br />
Ciprofloxacin, both given by intravenous route and oral route follows two-compartement <br />
<br />
pharmacokinetic model. Pharmacokinetic parameters of ciprofloxacin in intravenous route are as follows: <br />
<br />
A= 20.686 ± 9.930 µg/mL, λ1= 8.024 ± 1.947/hour, B= 2.303 ± 0.585 µg/mL, λ2= 0.087± 0.038/hour, k12= <br />
<br />
6.045± 2.134 /hour, k21= 1.240± 0.961/hour, dan kel= 0.8270,564/jam /hour. Pharmacokinetic parameters <br />
<br />
of ciprofloxacin in oral route are as follows: A= 1.696 ± 1,168 µg/mL, λ1= 0.244 ± 0.187/hour, B= 1.380 ± <br />
<br />
0.653 µg/mL, λ2= 0.092 ± 0.044/hour, C= 0.938 ± 0.462 µg/mL, ka= 1.638 ± 1.070/hour, k12 = 0.029 ± <br />
<br />
0.042/hour, k21= 0.206 ± 0.124/hour, dan kel= 0.102 ± 0,071 /hour. The calculated withdrawal time (WT) <br />
<br />
of ciprofloxacin based on Acceptable Daily Intake (ADI) information is 19.81 hours for intravenous route <br />
<br />
and 52.27 hours for oral route. In addition, the calculated WT of ciprofloxacin based on Maximum Residual <br />
<br />
Limit (MRL) information is 29.97 hours for intravenous route and 42.2 hours for oral route. <br />
|
|---|