#TITLE_ALTERNATIVE#

• Main Author: ADELA NIM : 11614002, MONIKA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29040
• Institution: Institut Teknologi Bandung

Ciprofloxacin is a broad spectrum antibiotic that is commonly used by breeders to cure chickens with <br /> <br /> bacterial disease. Concentration of ciprofloxacin in the poultry products should be under maximum <br /> <br /> residual limit (MRL) to prevent antimicrobial resistance. Therefore, pharmacokinetics parameters and <br /> <br /> withdrawal time of ciprofloxacin in the poultry products should be determined. In this research, ten laying <br /> <br /> hens were given ciprofloxacin by intravenous and oral route of administration. Twelve blood samples from <br /> <br /> each laying hens were then analysed by using High Performance Liquid Chromatography with UV detector. <br /> <br /> Ciprofloxacin, both given by intravenous route and oral route follows two-compartement <br /> <br /> pharmacokinetic model. Pharmacokinetic parameters of ciprofloxacin in intravenous route are as follows: <br /> <br /> A= 20.686 ± 9.930 µg/mL, &#955;1= 8.024 ± 1.947/hour, B= 2.303 ± 0.585 µg/mL, &#955;2= 0.087± 0.038/hour, k12= <br /> <br /> 6.045± 2.134 /hour, k21= 1.240± 0.961/hour, dan kel= 0.8270,564/jam /hour. Pharmacokinetic parameters <br /> <br /> of ciprofloxacin in oral route are as follows: A= 1.696 ± 1,168 µg/mL, &#955;1= 0.244 ± 0.187/hour, B= 1.380 ± <br /> <br /> 0.653 µg/mL, &#955;2= 0.092 ± 0.044/hour, C= 0.938 ± 0.462 µg/mL, ka= 1.638 ± 1.070/hour, k12 = 0.029 ± <br /> <br /> 0.042/hour, k21= 0.206 ± 0.124/hour, dan kel= 0.102 ± 0,071 /hour. The calculated withdrawal time (WT) <br /> <br /> of ciprofloxacin based on Acceptable Daily Intake (ADI) information is 19.81 hours for intravenous route <br /> <br /> and 52.27 hours for oral route. In addition, the calculated WT of ciprofloxacin based on Maximum Residual <br /> <br /> Limit (MRL) information is 29.97 hours for intravenous route and 42.2 hours for oral route. <br />