#TITLE_ALTERNATIVE#

• Main Author: ECKY BIONDI NIM: 20716027, MUHAMMAD
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29174
• Institution: Institut Teknologi Bandung

Scientific and technological development have positive impact on the psychotic <br /> <br /> management, in the case of schizophrenia by the discovery of first generation <br /> <br /> antipsychotics (APG-I) and second generation antipsychotics (APG-II). <br /> <br /> APG-I has limitations with the development of extra pyramidal syndrome (EPS) <br /> <br /> side effect which to be one of the factors for the patients to discontinue their <br /> <br /> treatment. Based on the patients’ medical record and observations of examination <br /> <br /> in psychiatric clinic at Soreng regional general hospital,, we found 223 patients <br /> <br /> with schizophrenia visited the clinic with the following details: 5,83 % <br /> <br /> patients without Trihexyphendyl (THP), 39,52 % patients have been <br /> <br /> discontinued using THP, and 127 patients on THP among which 19,69% <br /> <br /> with EPS. Patients were not treated with THP with the intention as <br /> <br /> prophylactic measure against EPS is 100 %. The use of THP in the clinic <br /> <br /> was seen to be decreased, either through dose reduction or its <br /> <br /> dinscontinuation. This reduction, however, had no effect on the appearance <br /> <br /> of EPS, indicating the appropriateness of the change in THP dose. But <br /> <br /> further assessment needs to be done on the possibility ofthe appearance of <br /> <br /> EPS in patients under APG I + THP. In this case, prescription adjustment <br /> <br /> might be required in the form of antipsychotic dose reduction and/or <br /> <br /> replacing APG I by APG II according to the presented symptoms <br />