#TITLE_ALTERNATIVE#
paracetamol as a primary reference standard has not been produced independently by the authorized <br /> <br /> institution in Indonesia. In order to initiate the independent procurement of primary reference standard, tIn <br /> <br /> order to initiate the independent provis...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/29485 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | paracetamol as a primary reference standard has not been produced independently by the authorized <br />
<br />
institution in Indonesia. In order to initiate the independent procurement of primary reference standard, tIn <br />
<br />
order to initiate the independent provision of primary reference standard, this research was conducted to <br />
<br />
obtain the high purity paracetamol as a primary reference standard candidate. In this research, purification <br />
<br />
of pharmaceutical grade paracetamol using recrystallization method in several organic solvents using thin <br />
<br />
layeryhigh performance liquid chromatography, FTIR y, nuclear magnetic resonance spectroscopyand is well <br />
<br />
as titrimetric assayThe results showed that was carried out. Then characterizatic and purity of <br />
<br />
recrystallization product was analyzed using thin layer chromatography, high performance liquid <br />
<br />
chromatography, FTIR spectroscopy, nuclear magnetic resonance spectroscopy, melting point analysis, loss <br />
<br />
on drying, residue on ignition analysis and nitrite titration. The result of this research showed that eethyl <br />
<br />
acetate was the most suitable solvent for paracetamol recrystallization. Based on overall characterization <br />
<br />
results, it was concluded that the purified paracetamol fullfilled the purity criteria as candidate primary <br />
<br />
standard with percentage of assigned value 99,96%. <br />
|
|---|