#TITLE_ALTERNATIVE#

• Main Author: ZAHRA SUGIARTO NIM : 10714052, NADIA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29485
• Institution: Institut Teknologi Bandung

paracetamol as a primary reference standard has not been produced independently by the authorized <br /> <br /> institution in Indonesia. In order to initiate the independent procurement of primary reference standard, tIn <br /> <br /> order to initiate the independent provision of primary reference standard, this research was conducted to <br /> <br /> obtain the high purity paracetamol as a primary reference standard candidate. In this research, purification <br /> <br /> of pharmaceutical grade paracetamol using recrystallization method in several organic solvents using thin <br /> <br /> layeryhigh performance liquid chromatography, FTIR y, nuclear magnetic resonance spectroscopyand is well <br /> <br /> as titrimetric assayThe results showed that was carried out. Then characterizatic and purity of <br /> <br /> recrystallization product was analyzed using thin layer chromatography, high performance liquid <br /> <br /> chromatography, FTIR spectroscopy, nuclear magnetic resonance spectroscopy, melting point analysis, loss <br /> <br /> on drying, residue on ignition analysis and nitrite titration. The result of this research showed that eethyl <br /> <br /> acetate was the most suitable solvent for paracetamol recrystallization. Based on overall characterization <br /> <br /> results, it was concluded that the purified paracetamol fullfilled the purity criteria as candidate primary <br /> <br /> standard with percentage of assigned value 99,96%. <br />