#TITLE_ALTERNATIVE#
The first line of peptic ulcer treatment, the proton pump inhibitor (PPI), is reported <br /> <br /> to induced hypergastrinemia and involved in gastrointestinal tumor growth in <br /> <br /> chronic use. An alternative therapy from natural sources was needed to minimize...
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Main Author: | |
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Format: | Theses |
Language: | Indonesia |
Online Access: | https://digilib.itb.ac.id/gdl/view/29824 |
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Institution: | Institut Teknologi Bandung |
Language: | Indonesia |
Summary: | The first line of peptic ulcer treatment, the proton pump inhibitor (PPI), is reported <br />
<br />
to induced hypergastrinemia and involved in gastrointestinal tumor growth in <br />
<br />
chronic use. An alternative therapy from natural sources was needed to minimize <br />
<br />
the risk. Turmeric (Curcuma domestica Val.) as well as propolis showed <br />
<br />
gastroprotective effect. This study aimed to determine gastroprotective effect of <br />
<br />
turmeric and propolis ethanolic extracts in fixed dose combination (FDC). <br />
<br />
Turmeric and propolis ethanolic extracts were formulated with pharmaceutical <br />
<br />
excipients to form three types of FDC. FDCs were given to ethanol-induced ulcer <br />
<br />
animal model. Then, animals were sacrificed and the stomach were isolated for <br />
<br />
macroscopic and microscopic examination. The results showed that FDC I, FDC <br />
<br />
II and FDC III significantly protected the stomach from ethanol-induced ulcer <br />
<br />
(p<0.05) based on number of ulcer, severity of ulcer, total area and percentage <br />
<br />
area of ulcer, and ulcer index. Percentage of protection from the greatest were FDC <br />
<br />
III (73.67%), FDC II (70.53%), and FDC I (47.83%). Result from macroscopic <br />
<br />
examination was in line with histology examination which showed that FDC I, FDC <br />
<br />
II and FDC III prevented gastric submucosal and mucosal disruption. No <br />
<br />
differences among FDC I, FDC II, and FDC III observed based on number of ulcer, <br />
<br />
severity of ulcer, total area and percentage area of ulcer, and ulcer index. In <br />
<br />
conclusion, FDC I, FDC II, and FDC III had gastroprotective effect in ethanolinduced ulcer model as shown in macroscopic and microscopic examination, with <br />
<br />
the most potent effect shown by FDC III. <br />
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