#TITLE_ALTERNATIVE#

• Main Author: SHAFIQAH PALAWANGI NIM : 11614764, NURUL
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29846
• Institution: Institut Teknologi Bandung

Garlic (Allium sativum) are having its own pharmacological activity. Garlic extract contained secondary <br /> <br /> metabolite such as flavonoid, saponin and steroid/tripernoid. Garlic, traditionally used to treat infections, <br /> <br /> colds, diabetes, heart disease and a host of other disorders. Clinically, it has been evaluated for lowering <br /> <br /> blood pressure, cholesterols and glucose concentrations, as well as for the prevention of cancer. The <br /> <br /> objective of this research is to find the best formulation for the preparation of capsules by using garlic <br /> <br /> powder and garlic extract. This research also conducted to determine the best excipients for the capsules <br /> <br /> based on the stability result. Steps of this research include preparation of garlic powder and garlic extract, <br /> <br /> standardization of the garlic powder and garlic extract, photochemistry screening, formulation and <br /> <br /> product evaluation using quantitative and semi-quantitative method. Garlic powder has normal density <br /> <br /> of 0.70g/ml, compressed density of 0.98g/ml, 2.76% moisture content, 62.50% water soluble content and <br /> <br /> 10.00% ethanol soluble content. From the best evaluation of the product, capsules that was containing <br /> <br /> garlic extract and avicel as the filler provide the best results of its stability. The chromatogram pattern of <br /> <br /> the product showing that the active compound of garlic extract is still obtained and chromatogram pattern <br /> <br /> is similar to the first week of the chromatogram pattern. The compressibility (K %), compression level (T <br /> <br /> %) and flow test (A) provided very good properties in each capsule.