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Molecular Imprinted Polymers (MIP) is a polymer made by molecular imprinting technology, MIP is <br /> <br /> able to recognize and bind selectively and specifically target molecules. Ranitidine is histamine H2 <br /> <br /> antagonists drug class and used for treatment gastr...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/30460 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Molecular Imprinted Polymers (MIP) is a polymer made by molecular imprinting technology, MIP is <br />
<br />
able to recognize and bind selectively and specifically target molecules. Ranitidine is histamine H2 <br />
<br />
antagonists drug class and used for treatment gastric ulcers disease. The aim of this study was to <br />
<br />
synthesize MIP with ranitidine as a template molecule for the separation and analysis ranitidine in <br />
<br />
tablet. MIP was prepared by using ranitidine, methacrylic acid as functional monomer, ethylene <br />
<br />
glycol dimethacrylate (EGDMA) as a cross linker, 2,2'-azobisisobutironitril (AIBN) as an initiator, and <br />
<br />
chloroform as porogenic solvent. Ratio of template molecules, functional monomers, and cross <br />
<br />
linker is 1: 4: 20 (mol). Characterization of MIP was performed by infrared spectroscopy, adsorption <br />
<br />
and desorption capacity test imprinting factor 1,7, and selectivity test. Ranitidine tablet that was <br />
<br />
extracted basically with chloroform and passed into MISPE and NISPE resulted recovery of 83,11% <br />
<br />
for MIP and 32,01% for NIP. Verification of ranitidine analysis method with spectrophotometry UVvisible gave valid results. Linearity with r = 0,9996 and Vxo = 0,017%, accuracy with recovery 98,69- <br />
<br />
101,53%, and precision with variance coefficient = 0,56%. <br />
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