#TITLE_ALTERNATIVE#

• Main Author: FITRIANI NIM : 10714078, RIFA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/30460
• Institution: Institut Teknologi Bandung

Molecular Imprinted Polymers (MIP) is a polymer made by molecular imprinting technology, MIP is <br /> <br /> able to recognize and bind selectively and specifically target molecules. Ranitidine is histamine H2 <br /> <br /> antagonists drug class and used for treatment gastric ulcers disease. The aim of this study was to <br /> <br /> synthesize MIP with ranitidine as a template molecule for the separation and analysis ranitidine in <br /> <br /> tablet. MIP was prepared by using ranitidine, methacrylic acid as functional monomer, ethylene <br /> <br /> glycol dimethacrylate (EGDMA) as a cross linker, 2,2'-azobisisobutironitril (AIBN) as an initiator, and <br /> <br /> chloroform as porogenic solvent. Ratio of template molecules, functional monomers, and cross <br /> <br /> linker is 1: 4: 20 (mol). Characterization of MIP was performed by infrared spectroscopy, adsorption <br /> <br /> and desorption capacity test imprinting factor 1,7, and selectivity test. Ranitidine tablet that was <br /> <br /> extracted basically with chloroform and passed into MISPE and NISPE resulted recovery of 83,11% <br /> <br /> for MIP and 32,01% for NIP. Verification of ranitidine analysis method with spectrophotometry UVvisible gave valid results. Linearity with r = 0,9996 and Vxo = 0,017%, accuracy with recovery 98,69- <br /> <br /> 101,53%, and precision with variance coefficient = 0,56%. <br />