INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH

INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH

The adsorption and reiease process of indomethacin and diclofenac sodium by copolymer ammoniomethacrylate (Eudragit RL`''') at various pH values around the pKa of each substance had been studied. The percentage of both substances adsorbed by Eudragit RL* at pH below the pKa values of...

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Main Author: Mauludin, Rachmat
Format: Theses
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/3095
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:3095
spelling id-itb.:30952005-10-12T14:11:53ZINTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH Mauludin, Rachmat Indonesia Theses INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/3095 The adsorption and reiease process of indomethacin and diclofenac sodium by copolymer ammoniomethacrylate (Eudragit RL`''') at various pH values around the pKa of each substance had been studied. The percentage of both substances adsorbed by Eudragit RL* at pH below the pKa values of substances was higher than those at pH above the pKa. The adsorption of substances by copolymer was not affected by the pKa. The addition of sodium chloride as much as hundred times of the adsorbed subtances increased the release of indomethacin up to 34% and the addition of sodium chloride as much as thousand times of the adsorbed substances released 30% of indomethacin and 10% of diclofenac sodium from the copolymer. Results showed that the adsorption process of indomethacin and diclofenac sodium on the Eudragit R:'" was presumably caused by non-ionic electrostatic interaction text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description The adsorption and reiease process of indomethacin and diclofenac sodium by copolymer ammoniomethacrylate (Eudragit RL`''') at various pH values around the pKa of each substance had been studied. The percentage of both substances adsorbed by Eudragit RL* at pH below the pKa values of substances was higher than those at pH above the pKa. The adsorption of substances by copolymer was not affected by the pKa. The addition of sodium chloride as much as hundred times of the adsorbed subtances increased the release of indomethacin up to 34% and the addition of sodium chloride as much as thousand times of the adsorbed substances released 30% of indomethacin and 10% of diclofenac sodium from the copolymer. Results showed that the adsorption process of indomethacin and diclofenac sodium on the Eudragit R:'" was presumably caused by non-ionic electrostatic interaction
format Theses
author Mauludin, Rachmat
spellingShingle Mauludin, Rachmat
INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
author_facet Mauludin, Rachmat
author_sort Mauludin, Rachmat
title INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
title_short INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
title_full INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
title_fullStr INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
title_full_unstemmed INTERAKSI ANTARA INDOMETASIN DAN NATRIUM DIKLOFENAK DENGAN KOPOLIMER AMONIUMETAKRILAT : PROFIL ADSORPSI DAN PELEPASAN PADA BERBAGAI PH
title_sort interaksi antara indometasin dan natrium diklofenak dengan kopolimer amoniumetakrilat : profil adsorpsi dan pelepasan pada berbagai ph
url https://digilib.itb.ac.id/gdl/view/3095
_version_ 1822915032433819648

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