CARBON PASTE ELECTRODE MODIFIED WITH MOLECULARLY IMPRINTED POLY(3-AMINOPHENOL) AND POLY(2-AMINOPHENOL) FOR VOLTAMMETRIC DETERMINATION OF PARACETAMOL
Acetaminophen (N-acetyl-p-aminophenol or paracetamol) is one of the most commonly used analgesics and antipyretics. However, the use of paracetamol must be controlled for overdosing may lead to accumulation of toxic metabolites in human body and cause liver and kidney failure. Therefore, it requires...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/33663 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Acetaminophen (N-acetyl-p-aminophenol or paracetamol) is one of the most commonly used analgesics and antipyretics. However, the use of paracetamol must be controlled for overdosing may lead to accumulation of toxic metabolites in human body and cause liver and kidney failure. Therefore, it requires a simple yet sensitive and accurate method for paracetamol determination. In this study, a voltammetry method with molecularly imprinted polymer (MIP) modified carbon paste electrode (CPE) as working electrode had been developed. The monomers used for MIP modification were 3-aminophenol and 2-aminophenol. Modifications were conducted using cyclic voltammetry technique within a potential range of -0.2–1.0 V and scan rate of 100 mV/s in 0.03 M HClO4 as supporting electrolyte. The modified electrodes had a good repeatability with RSD of 1.85% from 10 repeated measurements and a good reproducibility with RSD of 4.90% obtained using 5 electrodes. The calibration curve was linier at the concentration range of 0.001 mM - 1 mM with a detection limit of 0.74 µM. |
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