Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method
Artelasticin is classified as a flavonoid and has cytotoxic propert y against P388 cell tumor with LCso = 3.0 Jlg/mL. Artelasticin can be extracted from Artocarpus lanceifolius, but it gives a very low yield. To be able to maximize this compound, the synthesis of Artelasticin must be conducted. Th...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/38463 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Artelasticin is classified as a flavonoid and has cytotoxic propert y against P388 cell tumor with LCso = 3.0 Jlg/mL. Artelasticin can be extracted from Artocarpus lanceifolius, but it gives a very low yield. To be able to maximize this compound, the synthesis of Artelasticin must be conducted. The reaction mechanism of Artelasticin synthesis has been detennined from the derivative of acetophenone with (Mn l 5/6-31G(d)//RHF/6-31 G(d)) method. The energy of every species in this reaction mechanism has been determined. The Artelasticin synthesis reaction is exothermic, wi thout the inclusion of the protection and deprotection reactions of the hydroxyl group. The rate-determining step in the Artelasticin synthesis reaction is the ring fonnation of the prenylated P-diketone compou nd.
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