Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method
Artelasticin is classified as a flavonoid and has cytotoxic propert y against P388 cell tumor with LCso = 3.0 Jlg/mL. Artelasticin can be extracted from Artocarpus lanceifolius, but it gives a very low yield. To be able to maximize this compound, the synthesis of Artelasticin must be conducted. Th...
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id-itb.:384632019-05-27T08:11:46ZStudy of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method Leslie, Alexander Kimia Indonesia Final Project mechanism, synthesis, computational, energy, rate INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/38463 Artelasticin is classified as a flavonoid and has cytotoxic propert y against P388 cell tumor with LCso = 3.0 Jlg/mL. Artelasticin can be extracted from Artocarpus lanceifolius, but it gives a very low yield. To be able to maximize this compound, the synthesis of Artelasticin must be conducted. The reaction mechanism of Artelasticin synthesis has been detennined from the derivative of acetophenone with (Mn l 5/6-31G(d)//RHF/6-31 G(d)) method. The energy of every species in this reaction mechanism has been determined. The Artelasticin synthesis reaction is exothermic, wi thout the inclusion of the protection and deprotection reactions of the hydroxyl group. The rate-determining step in the Artelasticin synthesis reaction is the ring fonnation of the prenylated P-diketone compou nd. text |
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Kimia Leslie, Alexander Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
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Artelasticin is classified as a flavonoid and has cytotoxic propert y against P388 cell tumor with LCso = 3.0 Jlg/mL. Artelasticin can be extracted from Artocarpus lanceifolius, but it gives a very low yield. To be able to maximize this compound, the synthesis of Artelasticin must be conducted. The reaction mechanism of Artelasticin synthesis has been detennined from the derivative of acetophenone with (Mn l 5/6-31G(d)//RHF/6-31 G(d)) method. The energy of every species in this reaction mechanism has been determined. The Artelasticin synthesis reaction is exothermic, wi thout the inclusion of the protection and deprotection reactions of the hydroxyl group. The rate-determining step in the Artelasticin synthesis reaction is the ring fonnation of the prenylated P-diketone compou nd.
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| format |
Final Project |
| author |
Leslie, Alexander |
| author_facet |
Leslie, Alexander |
| author_sort |
Leslie, Alexander |
| title |
Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
| title_short |
Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
| title_full |
Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
| title_fullStr |
Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
| title_full_unstemmed |
Study of the Reaction Mechanism of Arielasticin Synthesis with Mn15/6-31G(d)//RHF/6-31G(d) Method |
| title_sort |
study of the reaction mechanism of arielasticin synthesis with mn15/6-31g(d)//rhf/6-31g(d) method |
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https://digilib.itb.ac.id/gdl/view/38463 |
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