KAJIAN EFEK IMUNOMODULATOR EKSTRAK DAUN KELOR (MORINGA OLEIFERA LAM.) PADA MENCIT SWISS WEBSTER

• Main Author: Yulianti, Ivana
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44212
• Institution: Institut Teknologi Bandung

The immune system is a system to protect the body from infectors. Currently many diseases related to the immune system such as lupus, rheumatoid arthritis, and AIDS. Therefore, drugs are needed to overcome diseases related to the immune system, which is known as immunomodulators. Immunomodulators can be obtained from plants as carried out in this study. Moringa leaves are traditionally used to maintain our health. The purpose of this study was to examine the immunomodulatory effects of moringa leaves extract on Swiss Webster mice. Two kinds of extracts were prepared, i.e., ethanol extract that obtained by maceration method and ethyl acetate extract produced by reflux method. Two doses of the extracts were test i.e., 75 and 150 mg/kg mice body weight. Ethyl acetate extract was also tested in the nanosuspension dosage form. Effect on immune responses was studied through carbon clearance tests to determine effects on nonspecific immune response, antibody titers and cytokine levels (IFN-?and IL-2) to determine effects on specific immune response. The results showed that ethanol extract at a dose of 75 mg/kg bw and both doses of ethyl acetate extract (75 and 150 mg/kg bw) showed immunostimulation effects (phagocytic index > 1.2). The nanosuspension of the ethyl acetate extract showed a stronger immunostimulation effect (phagocytic index> 1.5) than ethyl acetate extract. Both doses of ethanol extract, ethyl acetate, and nanosuspension of ethyl acetate extract have no effect on humoral immune response and the production of IFN-?and IL-2.