ANALISIS COST-EFFECTIVENESS PENGGUNAAN TRIHEKSIFENIDIL PADA PASIEN SKIZOFRENIA DI RUMAH SAKIT JIWA PROPINSI JAWA BARAT

• Main Author: Rahma Sitaagwa Zulaikha, Rally
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44402
• Institution: Institut Teknologi Bandung

Antipscychotic is a pharmacological therapy for schizophrenia which can cause extrapyramidal symptoms (EPS). Trihexyphenidyl (THP) is an anticholinergic to treat EPS that is used as a preventive and curative treatment. This study was aimed to conduct a cost-effectiveness analysis of THP as a preventive and curative treatment to treat EPS for schizophrenia patients in West Java Provincial Mental Hospital. There were 256 patients that fulfill the criteria, of which 72 patients were included. Medical record assessment was done to collect data on demography of the patients and the prescription pattern. The patients were then categorized based on the antipsychotic therapy and the usage of THP to treat EPS. The EPS score determined by a que????????ð??? ð????± »ð??±¸ ?????????­???????? ????ð±????????? ?¸????????????? ????ð±?????????????» ?ð?????????!»????±???????? ????¸????????????í± ????????????????®?????± ???? ???? ® ?®????? ????±¸ ????ð????í ????í± ???? ????ð±?????????????????í±???? ????????®?????????­????Incremental Cost-Effectiveness Ratio (ICER) method. There were two modes of treatment of THP to treat EPS, curative (65.3%) and preventive (34.7%). The mostly used antipsychotic was 2-drug combination of first generation antipsychotic-second generation antipsychotic (FGA-SGA) with curative accounted for 23.6% and preventive for 11.1%. The lowest ICER score was found in 3-drug combination of FGA-SGA with the consequence of highest financial lost by the use of THP as preventive treatment. Whereas, the highest ICER score was found with the monotherapy of FGA that indicates the lowest financial lost with the use of THP as preventive treatment. Taken together, the results indicate that THP has been used without taken into consideration the class of antipsychotic drugs used.