FORMULATION AND EVALUATION CAFFEINE PATCH AS AN ANTI-CELLULITE
Cellulite is a problem discovered since 1600, however not much research have been performed on cellulite. Caffeine is a methyl xanthine compound that could cause fat lipolysis in cellulite. In this current study, caffeine patch was formulated as an anti-cellulite. Caffeine patch was prepared usin...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/44459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Cellulite is a problem discovered since 1600, however not much research have
been performed on cellulite. Caffeine is a methyl xanthine compound that could
cause fat lipolysis in cellulite. In this current study, caffeine patch was
formulated as an anti-cellulite. Caffeine patch was prepared using solvent
evaporation????????method using variation polymers, including HPMC, Eudragit
L100-55, Eudragit RL dan PVP. Patch was then evaluated for its folding
endurance and mechanical strength, moisture and caffeine content. Release of
caffeine from the patch was evaluated in vitro and in vivo in rats. Efficacy of
the caffeine patch in reducing the adipose tissue was evaluated using
histopathology. The optimal formula of the patch was obtained using Eudragit
L100-55 with PEG 400 as a plasticizer and oleic acid as a penetration enhancer.
Results showed that the patch has a tensile strength value of 0.175±0.00 kg/mm
2
,
elongation of 1073.942±9.05 %, moisture content of 4.75±0.54 %, and caffeine
content of 98.43±4.08 %. Cumulative release of caffeine from the patch within
24 hours was 91.321±5.213 %. In vitro diffusion study showed a very low
amount of caffeine diffused through a snake skin membrane, however in vivo
study in rats showed a significant amount of caffeine found in the plasma.
Application of the preparations (caffeine patch and gel) daily for 21 days in rats
showed much lower caffeine plasma concentrations achieved from patch
application compared to gel application. Histopathology results showed a
significant reduction of the adipose tissue following application of the patch and
gel. The reduction of the adipose tissue were 50.92±10.82% and 61.06±3.42 %
(p<0.05) for patch and gel, respectively. Application of caffeine patch showed a
good efficacy with much lower plasma concentrations of caffeine compared to
gel. This might give a significant benefit in lowering the risk of caffeine side
effects due to systemic exposure.
|
|---|