FORMULATION AND EVALUATION CAFFEINE PATCH AS AN ANTI-CELLULITE

• Main Author: Purnamasari, Nira
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44459
• Institution: Institut Teknologi Bandung

Cellulite is a problem discovered since 1600, however not much research have been performed on cellulite. Caffeine is a methyl xanthine compound that could cause fat lipolysis in cellulite. In this current study, caffeine patch was formulated as an anti-cellulite. Caffeine patch was prepared using solvent evaporation????????method using variation polymers, including HPMC, Eudragit L100-55, Eudragit RL dan PVP. Patch was then evaluated for its folding endurance and mechanical strength, moisture and caffeine content. Release of caffeine from the patch was evaluated in vitro and in vivo in rats. Efficacy of the caffeine patch in reducing the adipose tissue was evaluated using histopathology. The optimal formula of the patch was obtained using Eudragit L100-55 with PEG 400 as a plasticizer and oleic acid as a penetration enhancer. Results showed that the patch has a tensile strength value of 0.175±0.00 kg/mm 2 , elongation of 1073.942±9.05 %, moisture content of 4.75±0.54 %, and caffeine content of 98.43±4.08 %. Cumulative release of caffeine from the patch within 24 hours was 91.321±5.213 %. In vitro diffusion study showed a very low amount of caffeine diffused through a snake skin membrane, however in vivo study in rats showed a significant amount of caffeine found in the plasma. Application of the preparations (caffeine patch and gel) daily for 21 days in rats showed much lower caffeine plasma concentrations achieved from patch application compared to gel application. Histopathology results showed a significant reduction of the adipose tissue following application of the patch and gel. The reduction of the adipose tissue were 50.92±10.82% and 61.06±3.42 % (p<0.05) for patch and gel, respectively. Application of caffeine patch showed a good efficacy with much lower plasma concentrations of caffeine compared to gel. This might give a significant benefit in lowering the risk of caffeine side effects due to systemic exposure.