Antihypertensive Effect Of Pluchea Indica L. Leaf Ethanolic Extract on Male Sprague Dawley Rats
Cardiovascular disease is one of the major causes of death in the world with hypertension as one of its risk factor. Hypertension can inhibit the supply of nutrients and oxygen to the tissues. Mostly, hypertension is caused by poor diet such as high consumption of salt in food. People usually use...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/44978 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Cardiovascular disease is one of the major causes of death in the world with hypertension as one
of its risk factor. Hypertension can inhibit the supply of nutrients and oxygen to the tissues.
Mostly, hypertension is caused by poor diet such as high consumption of salt in food. People
usually use traditional plant to reduce blood pressure for example celery, garlic, cucumber, etc.
Pluchea indica L. (Beluntas) is a plant that is widely used as a hedge that is very easy to get and
also there are no data on its benefit as an antihypertensive. This study aimed to test the
antihypertensive activity of ethanolic extract of Pluchea indica L. leaf. The active compounds from
beluntas leaves were extracted using Soxhlet method with 96% ethanol as solvent. The
experiment was conducted on male Sprague Dawley rats that were induced with a combination of
2% NaCl 0,2 g/kg bw and 1,5 mg/kg bw prednisone orally once a day for 14 consecutive days.
Extract 100 mg/kg bb, 300 mg/kg bw and 2,25 mg captopril were given orally once a day for 7
consecutive day. Sistolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured
the day before induction (H0), after induction (H7 dan H14), and after administration of the extract
(H21) using non-invasive direct tail-cuff CODA Instrument®. Results showed that the rats increased
in SBP (p<0,05) after 7 days of induction. The two doses of extract reduce SBP (26,7% for low dose
and 26,4% for high dose) and DBP (31,6% for low dose and 30,0% for high dose) significantly
(p<0,05) after 7 days extract administration. The two doses of extract gave similar potention as
captopril in reducing SBP and DBP. Based on the result, it can be concluded that the two doses of
beluntas leaf ethanolic extract have antihypertensive effect.
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