EVALUASI SERBUK BAGI RIFAMPISIN DUA DOSIS BERBEDA PADA SALAH SATU RUMAH SAKIT TIPE B JAWA BARAT
Tuberculosis (TB) is an infectious disease with a high case in Indonesia, and Indonesia is the 2nd rank country in the world with the highest case of TB. In Indonesia, the most TB cases in pediatric occurs in West Java. Nowadays, medication for TB patients is arranged as simple as possible to incr...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45152 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Tuberculosis (TB) is an infectious disease with a high case in Indonesia, and Indonesia is the 2nd rank
country in the world with the highest case of TB. In Indonesia, the most TB cases in pediatric occurs
in West Java. Nowadays, medication for TB patients is arranged as simple as possible to increase
? ?ð±??’? ¸í±?±?®±????????±?±??????í±?± ?± ??ð????¸??ã??í ??±±¸ ¸??± ¸ü????±?? ?±¸ on
? ?ð±??’??¸??±ðãí?, especially for pediatric patients. Rifampicin is one of antiTB drugs usually
ãð?±?ð?¸ð?𸱸 ???¸±???íð®í ?ð???ð»??í± ¸??± ¸ü????±?? ?¸ ®íð?¸?±?’? ®®±?? ?®±????íð?
compounding process of divided powders might be one factor that contributes to medication
errors. The purpose of this study was to evaluate weight variability and content uniformity and also
evaluate correlation between dose and number of samples that out of the tolerance limits. Five
pharmacy assistants in the studied hospital participated in this current study. Fifteen rifampicin
divided powders were prepared for the dose of 125 mg and 225 mg. The process was repeated 3
times in different days for each staff. All samples were evaluated for weight variability and content
uniformity using spectrophotometer visible and the tolerance limits of ±10%, ±15%, and ±25% was
used for the evaluation. From the total of 225 divided powders of 125 mg dose, there were 55.11%,
36%, and 15.56% samples which did not meet the tolerance limit of ±10%, ±15%, and ±25%,
respectively. A better result was shown for divided powder of 225 mg, there were 36.44%, 18.67%,
and 4.89% that out of the tolerance limit of ±10%, ±15%, and ±25%, respectively. Evaluation of
divided powders showed unsatisfied weight variation and content uniformity, which might lead to
ineffectiveness of TB therapy in pediatric patients.
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