UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL HERBA SELASIH (Ocimum basilicum) UNTUK MENGHAMBAT PERTUMBUHAN JAMUR KETOMBE (Malassezia furfur)

• Main Author: Mulyatini, Yulia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45440
• Institution: Institut Teknologi Bandung

Dandruff and seborrheic dermatitis is a common abnormal skin condition occurs on the scalp. The disorder is characterized by flaking and itching which caused by a fungal infection Malassezia furfur. Dandruff and seborrheic dermatitis therapy aims to reduce the number of M. furfur in the scalp, reducing in morbidity, and avoid complications. Ocimum basilicum or basil plant is a plant that has many benefits such as cough medicine, pesticide plant, essential oil, vegetables, and beverages. Essential oils of O. basilicum act as an antifungal. Basil essential oil contain linalool, fenchol, eugenol, metal chavicol, and acaryophyllene. This study aimed to determine the antifungal activity of ethanol extract of basil herb to inhibit the growth of dandruff fungus M. furfur, determine the diference between extract ethanol basil herb and ketoconazole in inhibiting growth of M. furfur, and also determine the equivalence between extract ethanol basil herb and ketoconazole. Parameter ethanol extract of basil herb activity against M. furfur is determined by measuring the diameter of inhibition using agar diffusion method. Then, the concentration of minimum inhibitory is determined by turbidimetry method and compared with ketoconazole. The ethanol extract of basil herb had activity to inhibit the growth of dandruff fungus M. furfur with minimum inhibitory concentration 25 mg/mL. The equivalence concentration between ethanol extract of basil herb and ketoconazole is 1 µg ketoconazole equivalent to 714.29 µg of ethanol extract of the basil herb. The ethanol extract of basil herb had antifungal activity to inhibit the growth of M. furfur. The minimum inhibitory concentration of ethanol extract of basil herb was 25 mg/mL. Ethanol extract of basil herb 714.29 µg was equivalent with ketoconazole 1 µg in inhibiting the growth of M. furfur.