AKTIVITAS ANTI-ARTRITIS REUMATOID EKSTRAK AIR TEH HIJAU [CAMELLIA SINENSIS (L.) KUNTZE] DAN DAUN ALPUKAT (PERSEA AMERICANA MILLER) PADA MODEL TIKUS ARTRITIS YANG DIINDUKSI DENGAN KOLAGEN
Rheumatoid arthritis (RA) is an autoimmune disease that affects not only the joints but also the body systemically. The release of cytokines, especially TNF-?, caused synovial inflammation leading to destruction of cartilage and joints which are the characteristics of RA. Analgesic and anti-infla...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45459 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Rheumatoid arthritis (RA) is an autoimmune disease that affects not only the joints but also
the body systemically. The release of cytokines, especially TNF-?, caused synovial
inflammation leading to destruction of cartilage and joints which are the characteristics of
RA. Analgesic and anti-inflammatory drugs are used to treat RA but long term usage of
such medication is associated with adverse reactions and discomfort. Natural plant
products that are beneficial against arthritis are continously being sought for the
management of RA. The objective of this research is to examine the anti-rheumatoid
arthritis activity of water extract of green tea [Camellia sinensis (L.) Kuntze] and avocado
(Persea americana Miller) leaves which is stated in literature have anti-inflammatory
activity. The research was begun with collecting, determining and characterization of the
test plant, extracting the active substances in water as traditional method, modelling of CIA
rats, followed by testing those extracts against CIA rats modelled. The presence of antiarthritic effect was determined through arthritis or macroscopic scoring, TNF-?
concentration, and histopathological study of rat’s limb tissue. Through arthritis scoring,
after the CIA rats treated with the two doses of green tea (72 and 216 mg/kg) and avocado
leaves (44 and 88 mg/kg) extracts, there was a decreased in macroscopic scoring. Under
TNF-?concentration determination, green tea at dose 216 mg/kg and the two doses of
avocado extracts reduced TNF-?concentration significantly (p<0.05). Through
microscopic examination of hind limb rat joint tissue, green tea at dose 216 mg/kg could
supress cartilage erosion better than other. Based on the results, it can be concluded that
water extract of green tea at dose 216 mg/kg has an anti-rheumatoid arthritis in CIA rat
model.
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