PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) TERHADAP PERBAIKAN FUNGSI GINJAL PADA MODEL TIKUS GAGAL GINJAL

• Main Author: Rachmamaryam, Shafia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45552
• Institution: Institut Teknologi Bandung

Kidney is one of vital organ which belong to urinary system. Renal failure occurs when the kidneys are unable to perform excretory functions which are important in maintaining homeostasis. Breadfruit leaves are commonly used empirically for the treatment of renal failure. This study aims to determine the influence of ethanol extract of breadfruit leaves to improve renal function in a renal failure rat model. Renal failure model was conducted by administering gentamicin with a dose of 100 mg/kg bw rats intraperitoneally for 7 days consecutively and piroxicam with the dose of 3.6 mg/kg bw for five week which is started together with gentamicin. Breadfruit leaves extract were given for four weeks of therapy at a dose of 50, 100, and 200 mg/kg bw began after gentamicin induction. Renal function were evaluated by measuring urea and creatinine serum levels at the beginning of study and every week, and it was followed by renal histology at the end of the experiment. After induction, urea and creatinine serum levels increase by five times than normal levels that different statistically (p < 0.05). During the treatment period, serum level of urea and creatinine in all group decreased on third week. There was a significant difference in urea and creatinine serum level in rats treated by 200 mg/kg breadfruit leaves. Histological results depicted an improvement of the kidney structure, especially on group of 200 mg/kg showed the most significant improvement. Ethanolic extract of breadfruit leaves improved kidney function in the renal failure rat model induced by gentamicin and piroxicam which was showed by reduction on the level of serum urea and creatinine, and improvement on kidney structure. Breadfruit 200 mg/kg bw showed better activity on ameliorating renal function according to this conducted research.