STUDY OF ETHNOPHARMACOLOGY IN TOBU HUKAEA-LAEA AND PHARMACOLOGY TEST OF MEDICINAL PLANT OF TOKULO (Kleinhovia hospita L.) AS ANTIINFLAMMATORY AND ANALGETIC
Introduction. Tobu Hukaea-Laea is indigenous tribe township of Moronene that lacoted in National Park of Rawa Aopa Watumohai. People who lives in this Tobu are native Moronene ethnic, they are believed to be the oldest ethnic in South East Sulawesi. Until now they still using part of plants for c...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45743 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Introduction. Tobu Hukaea-Laea is indigenous tribe township of Moronene that
lacoted in National Park of Rawa Aopa Watumohai. People who lives in this Tobu
are native Moronene ethnic, they are believed to be the oldest ethnic in South East
Sulawesi. Until now they still using part of plants for curing various diseases. Based
on ethnopharmacology study, there are various kind of plants that are still used as
medicine, one of them is tokulo (Kleinhovia hospita L.) which are commonly used as
painkillers and antiswelling.This research aims to prove the activity of
antiinflammatory and analgetic of tokulo. Methode. Etnofarmakologi initial
assessment is done through direct observation and interviews with quack
medicine, traditional leaders, and ordinary people who use medicinal plants in
Tobu Hukaea-Laea. The collected data was tabulated and one of the plant was
selected for the activity test of antiinflammatory and analgetic using
modificationmethde of Rendall-Selitto and Siegmund methode. Rendall-Selitto
modification method performed on Wistar rats induced by Complete Freund's
Adjuvant (CFA) in 0.1 mL intraplanar. Each test group was given ethanol extract
of tokulo leaf with dose of 35 mg/kg bw, 70 mg/kg bw, 140 mg/kg bw, as comparison
are 45 mg/kg bb of acetylsalisylic acid dan 0.36 mg/kg bb methyl
prednisolone.Siegmund methode performed on the Swiss-Webster mice induced
0.6% acetic acid intraperitonially. Each test group was given ethanol extract of
tokulo leaf with dose of 49 mg/kg bw, 98 mg/kg bw, 196 mg/kg bw and 65 mg/kg
bw of acetylsalicylic acid as comparison.Result. There are 34 plants that is still
used as medicine in Tobu Hukaea-Laea, include kambabulangoa, ikimko and
tokulo. The result of Rendall-Selitto modification methode showed that the ethanolic
extract with dose of 140 mg/kg bw gave antiinflammatory effect and for analgetic
effect was not appropriate with this methode. Based on Siegmund methode analgetic
effect was shown at the dose of 98 mg/kg bw.Conclusion. Plants are still used as
medicine in Tobu Hukaea-Laea are 34 plants one of them is Tokulo. Ethanolic extract
of tokulo with dose of 140 mg/kg bb shown antiinflammatory effect based on Rendall-
Selitto modification methode. Ethanolic extract with dose of 98 mg/kg bb shown the
greatest effect of analgetic based on Siegmund methode.
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