HEPATOPROTECTIVE ACTIVITY OF RICE FIELD SNAIL (Filopaludina javanica v.d Busch 1844) IN FEMALE WISTAR RATS INDUCED HEPATOTOXICITY BY PARACETAMOL
Rice field snail (Filopaludina javanica v.d Busch 1844) has been used empirically as a hepatoprotective agent. The snail is known rich of protein which is predicted to have a role in protecting the liver from damage. Its potential as a hepatoprotector still needs further proof, therefore this stu...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45818 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Rice field snail (Filopaludina javanica v.d Busch 1844) has been used empirically
as a hepatoprotective agent. The snail is known rich of protein which is predicted
to have a role in protecting the liver from damage. Its potential as a
hepatoprotector still needs further proof, therefore this study was conducted to
evaluate the effectiveness of the snail in preventing liver damage. The test was
performed by preventive method by administering paracetamol (360 mg/kg) as
inducer of liver damage for 14 days accompanied by administration of the snail
and silymarin (25 mg/kg) as a comparator drug. The snail were divided into three
parts of total flesh, flesh without rectum, and rectum flesh, each given in three
variations of dose. Body weight monitoring was performed during the treatment
and measurements of AST, ALT, and bilirubin levels were performed on days 0, 8,
and 15. On the 15
th
day, the organ index and histopathology of liver were
observed. This study showed that the snail inhibited liver damage caused by
paracetamol toxicity. The most effective part of the snail as a hepatoprotector was
the rectal flesh with the dose of 0.395 g/kg, which is equivalent to silymarin at 25
mg/kg.
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