HEPATOPROTECTIVE ACTIVITY OF RICE FIELD SNAIL (Filopaludina javanica v.d Busch 1844) IN FEMALE WISTAR RATS INDUCED HEPATOTOXICITY BY PARACETAMOL

• Main Author: Nurfazri Istiqomah, Aulia
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45818
• Institution: Institut Teknologi Bandung

Rice field snail (Filopaludina javanica v.d Busch 1844) has been used empirically as a hepatoprotective agent. The snail is known rich of protein which is predicted to have a role in protecting the liver from damage. Its potential as a hepatoprotector still needs further proof, therefore this study was conducted to evaluate the effectiveness of the snail in preventing liver damage. The test was performed by preventive method by administering paracetamol (360 mg/kg) as inducer of liver damage for 14 days accompanied by administration of the snail and silymarin (25 mg/kg) as a comparator drug. The snail were divided into three parts of total flesh, flesh without rectum, and rectum flesh, each given in three variations of dose. Body weight monitoring was performed during the treatment and measurements of AST, ALT, and bilirubin levels were performed on days 0, 8, and 15. On the 15 th day, the organ index and histopathology of liver were observed. This study showed that the snail inhibited liver damage caused by paracetamol toxicity. The most effective part of the snail as a hepatoprotector was the rectal flesh with the dose of 0.395 g/kg, which is equivalent to silymarin at 25 mg/kg.