THE EFFECT OF VITAMIN D SUPPLEMENTATION TO THE QUALITY OF LIFE OF NEW CASE TUBERCULOSIS PATIENTS
The incidence of tuberculosis (TB) is increasing with a high mortality rate. The severity of symptoms and impact of TB can affect patient quality of life. Several studies showed that vitamin D defficiency could decrease the immune response against Mycobacterium tuberculosis (Mtb). The objective...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/47102 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The incidence of tuberculosis (TB) is increasing with a high mortality rate. The
severity of symptoms and impact of TB can affect patient quality of life. Several
studies showed that vitamin D defficiency could decrease the immune response
against Mycobacterium tuberculosis (Mtb). The objective of this study is to
determine the effect of vitamin D supplementation to the quality of life (QoL) of
new case TB patients using St George’s Respiratory Questionnaire (SGRQ). This
SGRQ consist of 3 domains, i.e, symptoms, activity, and disease impact. This
study was carried out using a paired numerical analytical. Each group consist of
16 new case positive-smear TB patients. The test group received 800 IU of
vitamin D per day beside standard antituberculosis drugs. Result showed that
vitamin D supplementation increased the quality of life of new case TB patients
with NNT of 3.2. This value means that there is one of every 3 new case TB
patients received 800 IU of vitamin D per day will increase there quality of life.
The sputum conversion was higher in the vitamin D group compared to the
control group, i.e., 14(87,5%) vs 4(25%). Analyses of the three domains score of
SGRQ of vitamin D group showed that there was a very significant improvement
of patient QoL indicated from symptom score: 50.04±11.39 vs 12.46±12.04
(p=0.001), activity: 66.81±22.97 vs 27.00±17.02 (p=0.000), disease impact:
64.82±20.91 vs 11.63±13.94 (p=0.000), and the SGRQ total score: 62.87±18.5
and 16.43±13.06 (p=0.000). While the SGRQ score of the control group was no
different during study indicated from score for symptom: 46.42±17.34 vs
37.66±20.77 (p=0.127), activity: 62.12±17.54 vs 56.17±17.99 (p=0.435), disease
impact: 57.12±18.81 vs 41.67±21.15 (p=0.050), and the SGRQw total score:
55.97±15.89 and 47.33±18.05 (p=0.214). During study thare was also no
symptom of 800 IU vitamin D supplementation side effect observed. In
conclusion, vitamin D supplementation with a dose of 800 IU per day for one
month could increase the QoL of new case TB patients significantly.
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