THE EFFECT OF VITAMIN D SUPPLEMENTATION TO THE QUALITY OF LIFE OF NEW CASE TUBERCULOSIS PATIENTS

• Main Author: Alfiatusysyafiiyyah
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/47102
• Institution: Institut Teknologi Bandung

The incidence of tuberculosis (TB) is increasing with a high mortality rate. The severity of symptoms and impact of TB can affect patient quality of life. Several studies showed that vitamin D defficiency could decrease the immune response against Mycobacterium tuberculosis (Mtb). The objective of this study is to determine the effect of vitamin D supplementation to the quality of life (QoL) of new case TB patients using St George’s Respiratory Questionnaire (SGRQ). This SGRQ consist of 3 domains, i.e, symptoms, activity, and disease impact. This study was carried out using a paired numerical analytical. Each group consist of 16 new case positive-smear TB patients. The test group received 800 IU of vitamin D per day beside standard antituberculosis drugs. Result showed that vitamin D supplementation increased the quality of life of new case TB patients with NNT of 3.2. This value means that there is one of every 3 new case TB patients received 800 IU of vitamin D per day will increase there quality of life. The sputum conversion was higher in the vitamin D group compared to the control group, i.e., 14(87,5%) vs 4(25%). Analyses of the three domains score of SGRQ of vitamin D group showed that there was a very significant improvement of patient QoL indicated from symptom score: 50.04±11.39 vs 12.46±12.04 (p=0.001), activity: 66.81±22.97 vs 27.00±17.02 (p=0.000), disease impact: 64.82±20.91 vs 11.63±13.94 (p=0.000), and the SGRQ total score: 62.87±18.5 and 16.43±13.06 (p=0.000). While the SGRQ score of the control group was no different during study indicated from score for symptom: 46.42±17.34 vs 37.66±20.77 (p=0.127), activity: 62.12±17.54 vs 56.17±17.99 (p=0.435), disease impact: 57.12±18.81 vs 41.67±21.15 (p=0.050), and the SGRQw total score: 55.97±15.89 and 47.33±18.05 (p=0.214). During study thare was also no symptom of 800 IU vitamin D supplementation side effect observed. In conclusion, vitamin D supplementation with a dose of 800 IU per day for one month could increase the QoL of new case TB patients significantly.