KAJIAN PUSTAKA USAHA PENINGKATAN DISOLUSI RAMIPRIL DAN PENCEGAHAN SINTERING RAMIPRIL MELALUI PEMBENTUKAN KOKRISTAL SERTA SCREENING KOFORMERNYA SECARA IN SILICO
Ramipril is an angiotensin converting enzyme inhibitor (ACEI). Based on biopharmaceutical classification system (BCS), ramipril is classified as a class II drug that has low solubility and high permeability. Due to its low solubility, ramipril has a slow dissolution rate. Based on our previous re...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/50804 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Ramipril is an angiotensin converting enzyme inhibitor (ACEI). Based on biopharmaceutical
classification system (BCS), ramipril is classified as a class II drug that has low solubility and high
permeability. Due to its low solubility, ramipril has a slow dissolution rate. Based on our previous
research, ramipril underwent sintering during tabletation that decrease its dissolution rate
compared with its powder. Cocrystal formation is one of the most potential methods to increase
dissolution rate and to prevent sintering. Based on our literature study, cocrystal has shown to be
able to improve the physicochemical properties of various active pharmaceutical ingredients (APIs).
The successful formation of a cocrystal depends on the selection of coformer through coformer
screening. In this study, coformer screening is conducted in silico using the Cambridge Structural
Database (CSD). This screening method is based on the molecular-scale descriptor and the hydrogen
bond propensity. Hippuric acid, vanillin, and saccharin have a hit rate of 50, 80, and 30%, and
?propensity 0.1, 0.06, and 0.01, respectively. Based on this result, these three coformers could
potentially form cocrystals with ramipril.
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