KAJIAN PUSTAKA USAHA PENINGKATAN DISOLUSI RAMIPRIL DAN PENCEGAHAN SINTERING RAMIPRIL MELALUI PEMBENTUKAN KOKRISTAL SERTA SCREENING KOFORMERNYA SECARA IN SILICO

• Main Author: Akbar Rustandi, Fauzi
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/50804
• Institution: Institut Teknologi Bandung

Ramipril is an angiotensin converting enzyme inhibitor (ACEI). Based on biopharmaceutical classification system (BCS), ramipril is classified as a class II drug that has low solubility and high permeability. Due to its low solubility, ramipril has a slow dissolution rate. Based on our previous research, ramipril underwent sintering during tabletation that decrease its dissolution rate compared with its powder. Cocrystal formation is one of the most potential methods to increase dissolution rate and to prevent sintering. Based on our literature study, cocrystal has shown to be able to improve the physicochemical properties of various active pharmaceutical ingredients (APIs). The successful formation of a cocrystal depends on the selection of coformer through coformer screening. In this study, coformer screening is conducted in silico using the Cambridge Structural Database (CSD). This screening method is based on the molecular-scale descriptor and the hydrogen bond propensity. Hippuric acid, vanillin, and saccharin have a hit rate of 50, 80, and 30%, and ?propensity 0.1, 0.06, and 0.01, respectively. Based on this result, these three coformers could potentially form cocrystals with ramipril.