PREDIKSI INTERAKSI BEBERAPA SENYAWA ANTIKANKER YANG DILABEL DENGAN RADIONUKLIDA TEKNESIUM-99M TERHADAP TARGETNYA MENGGUNAKAN TEKNIK PENAMBATAN MOLEKUL
At present, the field of molecular imaging as a diagnostic method focuses on the development of radiopharmaceuticals that target the proliferation of DNA, mRNA, or protein molecules (receptors) that are characteristic of early cancer development. In this study, molecular docking techniques are us...
Saved in:
| Main Author: | |
|---|---|
| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/51362 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | At present, the field of molecular imaging as a diagnostic method focuses on the development of
radiopharmaceuticals that target the proliferation of DNA, mRNA, or protein molecules (receptors)
that are characteristic of early cancer development. In this study, molecular docking techniques are
used to predict interactions of anticancer drug molecules which are labeled with radioisotope of
technetium-99m as a new agent for cancer imaging. Eight anticancer compounds were labeled with
technetium-99m and molecular docking was carried out.
99m
Tc-azacitidine,
99m
Tc-dacarbazine,
99m
Tc-fluorouracil, and
99m
Tc-hydroxyurea have a good affinity for the p21 protein produced by Hras oncogens so that they can play a role in early detection of cancer. Whereas
99m
Tc-cytarabine,
99m
Tc-fludarabine, and
99m
Tc-bleomycin have good affinity for DNA. Molecular docking confirms
labeling with technetium for these compounds has little effect on the binding of compounds to
receptors and has the potential to be a new cancer imaging agent.
|
|---|