PREDIKSI INTERAKSI BEBERAPA SENYAWA ANTIKANKER YANG DILABEL DENGAN RADIONUKLIDA TEKNESIUM-99M TERHADAP TARGETNYA MENGGUNAKAN TEKNIK PENAMBATAN MOLEKUL

• Main Author: Cundasari, Riana
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/51362
• Institution: Institut Teknologi Bandung

At present, the field of molecular imaging as a diagnostic method focuses on the development of radiopharmaceuticals that target the proliferation of DNA, mRNA, or protein molecules (receptors) that are characteristic of early cancer development. In this study, molecular docking techniques are used to predict interactions of anticancer drug molecules which are labeled with radioisotope of technetium-99m as a new agent for cancer imaging. Eight anticancer compounds were labeled with technetium-99m and molecular docking was carried out. 99m Tc-azacitidine, 99m Tc-dacarbazine, 99m Tc-fluorouracil, and 99m Tc-hydroxyurea have a good affinity for the p21 protein produced by Hras oncogens so that they can play a role in early detection of cancer. Whereas 99m Tc-cytarabine, 99m Tc-fludarabine, and 99m Tc-bleomycin have good affinity for DNA. Molecular docking confirms labeling with technetium for these compounds has little effect on the binding of compounds to receptors and has the potential to be a new cancer imaging agent.