FORMULASI SEDIAAN KRIM DENGAN PEMBENTUKAN LIQUID CRYSTAL SERTA KAJIAN PUSTAKA KARAKTERISASI DAN PEMANFAATAN LIQUID CRYSTAL DALAM KRIM KAFEIN SEBAGAI ANTISELULIT

• Main Author: Anggraeni, Sheila
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/51710
• Institution: Institut Teknologi Bandung

Cellulite is a skin problem due to fluid retention and swelling of adiposite cells because of accumulation of fatty tissue. Caffeine has an anticelullite activity by induces lipolysis. Liquid crystal (LC) could be used as a caffeine carrier in topical dosage form because its amphiphilic property that might help caffeine pass through stratum corneum which acts a skin barrier. The purpose of this research was to develop LC system that could be used as anticellulite cream with caffeine as the active ingredient. Cream base of LC system was made from glyceryl monooleate (GMO)/water, and then characterized by polarized light microscopy (PLM). Literature review was aimed to find out the application of LC in topical formulation, LC characterization methods and caffeine activity as an anticellulite in topical dosage form. Literature searched was performed by PubMed and Google Scholar search engine with the keywords of (liquid crystal) AND (topical formulation); (liquid crystal) AND (characterization); and (((anticellulite) OR (anti cellulite) OR (anti-cellulite)) AND (caffeine)). Based on the literature review, the formula used was GMO, adeps lanae, soft paraffin, oleic acid, propylene glycol, glycerin, methyl paraben, propyl paraben, ?-tocopherol, and aquadest. LC phase formed was cubic, lamelar, and hexagonal in variant concentrations of GMO/aquadest. Based on the literature review, LC in topical dosage form could increase permeation, release, and penetration of the drug. LC could be characterized by PLM, small angle x-ray scattering (SAXS), differential scanning calorimetry (DSC), and rheometer. Caffeine showed an anticellulite activity by in vitro, ex vivo, in vivo, and also clinical test. Drug carrier modification showed the increase of its anticellulite activity. Formulation of LC with GMO/water system in caffeine cream is expected to increase the anticellulite activity.