PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI

PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI

<br /> An ion pair high performance liquid chromatographic method was developed for determination of ketamine hydrochloride in injection dosage form. Result showed that high performance liquid chromatographic method using a mixture of acetonitrrle-0.05 M phosphate buffer of pH 4.5 containing...

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Main Author: Kurnia Setiawan , Henry
Format: Theses
Language:Indonesia
Subjects:
Farmakologi dan terapeutik
Online Access:https://digilib.itb.ac.id/gdl/view/5255
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:5255
spelling id-itb.:52552006-03-20T13:34:05ZPENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Kurnia Setiawan , Henry Farmakologi dan terapeutik Indonesia Theses INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/5255 <br /> An ion pair high performance liquid chromatographic method was developed for determination of ketamine hydrochloride in injection dosage form. Result showed that high performance liquid chromatographic method using a mixture of acetonitrrle-0.05 M phosphate buffer of pH 4.5 containing 0.05% sodium hexane sulphonate (25:75) as mobile phase, flow rate of 1.0 mL/minute, C-18 column, and detection wavelength of 215 nm. The method validation with an external standard showed that the accuracy was 99.50±0.66 %, the limit of detection and limit of quantitation were 0.93 and 3.09 pg/mL, respectively. The method validation with atropine sulphate as an internal standard showed that the accuracy was 100.84±1.92 %, the limit of detection and limit of quantitation were 1.46 and 4.87 gg/mL, respectively. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
topic Farmakologi dan terapeutik
spellingShingle Farmakologi dan terapeutik
Kurnia Setiawan , Henry
PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
description <br /> An ion pair high performance liquid chromatographic method was developed for determination of ketamine hydrochloride in injection dosage form. Result showed that high performance liquid chromatographic method using a mixture of acetonitrrle-0.05 M phosphate buffer of pH 4.5 containing 0.05% sodium hexane sulphonate (25:75) as mobile phase, flow rate of 1.0 mL/minute, C-18 column, and detection wavelength of 215 nm. The method validation with an external standard showed that the accuracy was 99.50±0.66 %, the limit of detection and limit of quantitation were 0.93 and 3.09 pg/mL, respectively. The method validation with atropine sulphate as an internal standard showed that the accuracy was 100.84±1.92 %, the limit of detection and limit of quantitation were 1.46 and 4.87 gg/mL, respectively.
format Theses
author Kurnia Setiawan , Henry
author_facet Kurnia Setiawan , Henry
author_sort Kurnia Setiawan , Henry
title PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
title_short PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
title_full PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
title_fullStr PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
title_full_unstemmed PENETAPAN KADAR KETAMIN HIDROKLORIDA DALAM SEDIAAN INJEKSI DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI
title_sort penetapan kadar ketamin hidroklorida dalam sediaan injeksi dengan metode kromatografi cair kinerja tinggi
url https://digilib.itb.ac.id/gdl/view/5255
_version_ 1820663634858082304

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