INTERMOLECULAR INTERACTION STUDIES OF TELMISARTAN AND AMLODIPINE BESYLATE

• Main Author: Kurnia Utama, Vonny
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/54336
• Institution: Institut Teknologi Bandung

The combination of two active pharmaceutical ingredients in a single pharmaceutical dosage form can cause intermolecular interactions. Intermolecular interactions may affect the physicochemical properties of the constituent components. Identification of intermolecular interactions of the mixture of telmisartan (TMS) and amlodipine besylate (ADB) was carried out by the fusion, solid state grinding (SSG), solvent drop grinding (SDG) and solvent evaporation (SE) method in the 1:1 ratio molar. The fusion method in methanol solvent showed a new crystalline habit indicating the presence of intermolecular interactions. The TMS-ADB phase diagram indicated the occurrence of peritectic interactions. The DSC thermogram showed the presence of two endothermic peaks which are the melting points of the peritectic compound. Microscopic analysis by SEM of SDG method showed the agglomeration in the TMS-ADB mixture. The IR spectrum showed a shift in the wave number in the O-H and C = O stretch. X-ray diffractograms did not show any new crystalline phase. The solubility of the TMS after treatment in phosphate buffer medium pH 7.5 increased up to 3 times compared to its pure form.