FORMULASI DAN EVALUASI SEDIAAN MIKROSFER MENGAPUNG YANG MENGANDUNG GLIMEPIRID

• Main Author: Risalati, Azifa
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/54776
• Institution: Institut Teknologi Bandung

Glimepirid is a type 2 diabetes drug that is absorbed in the upper gastrointestinal tract. One constraint for drugs that absorbed in the upper gastrointestinal tract is a relatively short stomach residence time. This can make incomplete of drug absorbed and decreased the bioavailability of drug. One approach to prolong and control gastric residence time is by preparing gastroretentive drug delivery system such as floating dosage form. The aim of this study is to develop glimepiride controlled release floating microspheres by using emulsion solvent evaporation method. The formula that used consists of glimepiride as the active ingredient, ethyl cellulose and HPMC as a microsphere-forming polymer, Tween 80 as emulsifying agent and ethanol and dichloromethane as polymer solvent. Evaluation of the microspheres were done for the entrapment efficiency, the yield percentage, the appearance of microsphere, the particle size, the floating ability, the surface morphology , and the release of glimepirid from the microsphere. The best formula in this study is F9 that consists of ethyl cellulose: Glimepirid (1: 1) with the value of entrapment efficiency was 72.36 ± 2.01%. Rendemen of this formula was 77.9%. The mean particle size of the F9 microspheres was 83.38 ± 53.33??. After 12 hours, about 61.87 ± 2.11% of the microspheres were still float in the simulation gastric fluid medium. The morphology of the surface of the microspheres revealed by scanning electron microscope showed that the microspheres were sphere-shaped with rough surfaces. The amount of glimepirid released from the F9 microsphere after 12 hours was 50.09 ± 0.56%.