KAJIAN PUSTAKA SEDIAAN KOLOIDAL BERBASIS LIPID: SOLID LIPID NANOPARTICLES DAN NANOSTRUCTURED LIPID CARRIERS SERTA APLIKASINYA DALAM SEDIAAN TOPIKAL DAN KOSMETIK BERBAHAN ALAM

• Main Author: Graciela, Clarissa
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56398
• Institution: Institut Teknologi Bandung

The stratum corneum is the outermost barrier that protects the body against penetration of chemicals and microbes. The stratum corneum layer then became a challenge in the development of the topical delivery system. For both topical drugs and cosmetics, it is desirable that the active substance remains in the epidermis for a sufficiently long time to obtain the desired effect without reaching the circulatory system. This literature review aimed to analyze the potential of the use of lipid-based colloidal carriers in the form of solid lipid nanoparticles and nanostructured lipid carriers in topical drugs and cosmetics made from natural ingredients. The search for data relevant to the topic of literature review was carried out through the Google Scholar search engine and the PubMed database. This literature review included a summary of the latest developments in lipid-based colloidal carriers in natural-based topical drugs and cosmetics, analysis of the effects resulting from the implementation of these lipid-based colloidal carriers, regulation of nanoparticles, and prediction of prospects for lipidbased colloidal carriers in topical drugs and cosmetics. and regulation of nanoparticles. Based on the results of the literature review, there were several advantages of lipid-based colloidal carriers, namely the occlusion effect, increased penetration, increased drug stability, increased drug-skin contact time, and decreased drug side effects. Lipid-based colloid carriers have been widely used in topical drugs with various indications as well as in cosmetics such as sunscreens, moisturizers, antioxidants, and antiaging.