IDENTIFICATION OF ADVERSE DRUG REACTIONS (ADR) AND TREATMENT IN CONFIRMED FOR COVID-19 INPATIENTS AT DR. WAHIDIN SUDIROHUSODO MAKASSAR HOSPITAL
Coronavirus Disease 2019 (COVID-19) is infection disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel Coronavirus that has not been previously identified in humans. COVID-19 cases continue to increase every day around the world until WHO has declared COVID-19 as...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/56403 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Coronavirus Disease 2019 (COVID-19) is infection disease caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a novel Coronavirus that has
not been previously identified in humans. COVID-19 cases continue to increase
every day around the world until WHO has declared COVID-19 as a global
pandemic. Until mid-May 2021, the Case Fatality Rate (CFR) COVID-19 cases in
Indonesia reaches 2,76%. Several types of antivirals and antibiotics have become
options in the treatment of COVID-19, but apart from considering the efficacy, the
safety factor of their use must also be considered. This study aims to determine the
profile of adverse drug reactions (ADR) in patients with COVID-19 that admitted
to the Dr. Wahidin Sudirohusodo Hospital in Makassar on November - December
2020, and determine the level of probability and severity of the ADR. Retrospective,
cross-sectional study has been conducted to 176 patients who met inclusion and
exclusion criteria and classified into 2 groups, a group without ADR and a group
with ADR, then identified the probability and severity level of ADR with the Naranjo
Algorithm and Hartwig-Siegel scale. Results showed that the prevalence of ADRs
was 31% in the patients, which was predominated by drug-induced gastrointestinal
disorders and liver system disorders (21.59% and 22.73%). ADR that occurs has a
probability of 75% is “probable” and 25% is “possible”, while the severity of ADR
that occurs is 78% at level 3 (moderate) and 22% at level 2 (mild). There were
96,7% of ADRs that occured within 14 days of hospitalization. The results of
statistical analysis showed an association between age, length of stay and the
number of drugs used during hospitalization with the incidence of ADR (p-value
<0.05) statistically significant. Most of the incidence of Adverse Drug Reactions
that occurred was due to the use of oseltamivir (48.9%) and azithromycin (45.7%)
with the precentage of cure from ADR, respectively, 42.4% and 37%.
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