KAJIAN TEORITIS EKSTRAK DAUN SIRIH (PIPER BETLE L.) DAN PENGARUH PENAMBAHANNYA PADA FORMULA HAND SANITIZER TERHADAP PENINGKATAN AKTIVITAS ANTIBAKTERI

• Main Author: Apelianti, Triani
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56462
• Institution: Institut Teknologi Bandung

SARS-CoV-2 is the cause of COVID-19 (Coronavirus Disease 2019), a contagious disease that has spread worldwide, causing a global health crisis. Other than COVID-19, there are also other diseases caused by pathogen transmission by hands. To prevent it, keeping hand hygiene by washing hands with soap is a measure that has been proven effective. If water and soap are not available, hand sanitizer can be an effective alternative that also can be easily used. WHO recommends alcohol based hand sanitizer because its wide microbicidal spectrum, and concentration over 60% is effective to kill SARS-CoV-2. The literature study aims to analyze hand sanitizer formulation and the possibility of betel leaves extract fortification in hand sanitizer to increase its antimicrobial activity. A literature study for alcohol-based hand sanitizer gel formulation incorporating betel leaf extract was conducted. Papers were collected from search engine and electronic databases Google Scholar and PubMed. Datas were extracted and informations were collected to be analyzed. Betel leaf extract possesses medium to strong antibacterial activity, which is caused by its component, eugenol and hydroxychavicol. Some papers stated the compatibility of ethanol, Carbopol 940, triethanolamine, and glycerin for alcohol-based hand sanitizer formulation that could produce a stable and well-accepted product. Suitable method for alcohol-based hand sanitizer making is direct addition or reverse addition, which depends on available equipment for production. Moreover, formulation of alcohol-based hand sanitizer gel formulation incorporating plant extract has been proven to increase the antibacterial activity of preparation towards pathogen. Based on the component analysis, betel leaf extract, tocopherol, ethanol, Carbopol 940, triethanolamine, and glycerin can produce hand sanitizer gel with good effectivity and stability thus further research should be conducted.