KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain, fever, swelling, or stiffness caused by arthritis and dysmenorrhea. Based on Biopharmaceutical Classification System (BCS), naproxen is classified as Class II drug with aqueous solubility of 15.9 mg/...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/56579 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain,
fever, swelling, or stiffness caused by arthritis and dysmenorrhea. Based on Biopharmaceutical
Classification System (BCS), naproxen is classified as Class II drug with aqueous solubility of 15.9 mg/L
at 25?C. The bioavailability of BCS Class II drugs is limited by their solubility. Cocrystal formation is one
of few methods to increase solubility of drugs. Hence in this study, we aim to increase the solubility of
naproxen by cocrystal formation. Coformer selection is one of the most important steps in cocrystal
formation. In this study, coformer selection is conducted via in silico screening using Cambridge
Structural Database (CSD). Naproxen and a set of prospective coformers will go through two stage
screening procedure i.e. molecular complementarity and hydrogen bonding propensity. Based on this
screening process and literature review, resorcinol is a potential coformer for naproxen to form higher
solubility cocrystals. This screening result can be used as a guidance for experimental cocrystal
screening.
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