KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO

KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain, fever, swelling, or stiffness caused by arthritis and dysmenorrhea. Based on Biopharmaceutical Classification System (BCS), naproxen is classified as Class II drug with aqueous solubility of 15.9 mg/...

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Main Author: Giovanni
Format: Final Project
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/56579
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:56579
spelling id-itb.:565792021-06-23T10:36:12ZKAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO Giovanni Indonesia Final Project Naproxen, solubility, cocrystal, coformer, screening, Cambridge Structural Database INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/56579 Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain, fever, swelling, or stiffness caused by arthritis and dysmenorrhea. Based on Biopharmaceutical Classification System (BCS), naproxen is classified as Class II drug with aqueous solubility of 15.9 mg/L at 25?C. The bioavailability of BCS Class II drugs is limited by their solubility. Cocrystal formation is one of few methods to increase solubility of drugs. Hence in this study, we aim to increase the solubility of naproxen by cocrystal formation. Coformer selection is one of the most important steps in cocrystal formation. In this study, coformer selection is conducted via in silico screening using Cambridge Structural Database (CSD). Naproxen and a set of prospective coformers will go through two stage screening procedure i.e. molecular complementarity and hydrogen bonding propensity. Based on this screening process and literature review, resorcinol is a potential coformer for naproxen to form higher solubility cocrystals. This screening result can be used as a guidance for experimental cocrystal screening. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is generally used to reduce pain, fever, swelling, or stiffness caused by arthritis and dysmenorrhea. Based on Biopharmaceutical Classification System (BCS), naproxen is classified as Class II drug with aqueous solubility of 15.9 mg/L at 25?C. The bioavailability of BCS Class II drugs is limited by their solubility. Cocrystal formation is one of few methods to increase solubility of drugs. Hence in this study, we aim to increase the solubility of naproxen by cocrystal formation. Coformer selection is one of the most important steps in cocrystal formation. In this study, coformer selection is conducted via in silico screening using Cambridge Structural Database (CSD). Naproxen and a set of prospective coformers will go through two stage screening procedure i.e. molecular complementarity and hydrogen bonding propensity. Based on this screening process and literature review, resorcinol is a potential coformer for naproxen to form higher solubility cocrystals. This screening result can be used as a guidance for experimental cocrystal screening.
format Final Project
author Giovanni
spellingShingle Giovanni
KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
author_facet Giovanni
author_sort Giovanni
title KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
title_short KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
title_full KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
title_fullStr KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
title_full_unstemmed KAJIAN PUSTAKA PENINGKATAN KELARUTAN NAPROKSEN MELALUI PEMBUATAN KOKRISTAL DENGAN SCREENING KOFORMER SECARA IN SILICO
title_sort kajian pustaka peningkatan kelarutan naproksen melalui pembuatan kokristal dengan screening koformer secara in silico
url https://digilib.itb.ac.id/gdl/view/56579
_version_ 1822274639449030656

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