SAMBUNG SILANG PATI DENGAN POLIMER LAIN UNTUK DIJADIKAN EKSIPIEN SEDIAAN FARMASI
Starch is an abundant, inexpensive biopolymer that can be metabolized by the human body, so it has been widely used as an excipient in pharmaceutical formulations. The disadvantages of starch include poor flow properties, limited compressibility, reduced solubility in water, low paste strength, a...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/56592 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Starch is an abundant, inexpensive biopolymer that can be metabolized by the human body, so it
has been widely used as an excipient in pharmaceutical formulations. The disadvantages of starch
include poor flow properties, limited compressibility, reduced solubility in water, low paste
strength, and tendency to retrogradation and decomposition, have made it necessary to modify it
in various ways, one of which was by crosslinking with other polymers. This article review has
described which polymers can be crosslinked with starch, as well as their characteristics that
demonstrate their suitability as pharmaceutical excipients. Article review has been carried out by
derivating topics into information points, browsing and selecting scientific articles according to
inclusion criteria, analyzing and synthesizing selected articles, becoming references for future
research and understanding some polymers that can be crosslinked with starch to be a
pharmaceutical excipient. Natural polymers such as xanthan gum, chitosan, karaya gum,
carrageenan, carboxymethyl cellulose sodium, CMC-Na, and also synthetic polymers such as
polyacrylic acid, PAA, polyethylene glicol, PEG, polyvinyl alcohol, PVA, and polyvinyl pyrrolidone,
PVP have been crosslinked with starch, and they have been used as excipients for pharmaceutical
preparations. These crosslinked products as hydrogel, nanogel, and fungtional biomaterial, has a
good swelling and drug release characteristics in drug delivery systems.
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