SAMBUNG SILANG PATI DENGAN POLIMER LAIN UNTUK DIJADIKAN EKSIPIEN SEDIAAN FARMASI

• Main Author: Ivana Agatha, Laurensia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/56592
• Institution: Institut Teknologi Bandung

Starch is an abundant, inexpensive biopolymer that can be metabolized by the human body, so it has been widely used as an excipient in pharmaceutical formulations. The disadvantages of starch include poor flow properties, limited compressibility, reduced solubility in water, low paste strength, and tendency to retrogradation and decomposition, have made it necessary to modify it in various ways, one of which was by crosslinking with other polymers. This article review has described which polymers can be crosslinked with starch, as well as their characteristics that demonstrate their suitability as pharmaceutical excipients. Article review has been carried out by derivating topics into information points, browsing and selecting scientific articles according to inclusion criteria, analyzing and synthesizing selected articles, becoming references for future research and understanding some polymers that can be crosslinked with starch to be a pharmaceutical excipient. Natural polymers such as xanthan gum, chitosan, karaya gum, carrageenan, carboxymethyl cellulose sodium, CMC-Na, and also synthetic polymers such as polyacrylic acid, PAA, polyethylene glicol, PEG, polyvinyl alcohol, PVA, and polyvinyl pyrrolidone, PVP have been crosslinked with starch, and they have been used as excipients for pharmaceutical preparations. These crosslinked products as hydrogel, nanogel, and fungtional biomaterial, has a good swelling and drug release characteristics in drug delivery systems.