UJI TOLERANSI GLUKOSA EKSTRAK DAUN KATUK (SAUROPUS ANDROGYNUS (L.) MERR.) PADA MENCIT SWISS WEBSTER JANTAN DAN STUDI LITERATUR EKSTRAK TANAMAN YANG BERPOTENSI SEBAGAI ANTIDIABETES
Diabetes mellitus (DM) is a non-communicable disease caused by carbohydrate metabolism disorders and is characterized by chronic hyperglycemia. Traditional herbal medicines are widely used in several countries to treat chronic and non-communicable diseases such as DM. Katuk (Sauropus androgynus (...
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Format: | Final Project |
Language: | Indonesia |
Online Access: | https://digilib.itb.ac.id/gdl/view/61962 |
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Institution: | Institut Teknologi Bandung |
Language: | Indonesia |
Summary: | Diabetes mellitus (DM) is a non-communicable disease caused by carbohydrate metabolism
disorders and is characterized by chronic hyperglycemia. Traditional herbal medicines are widely
used in several countries to treat chronic and non-communicable diseases such as DM. Katuk
(Sauropus androgynus (L.) Merr.) has been widely used by Indonesian people as a lactation
enhancer. In India, katuk is known as an antidiabetic agent. There have not been many studies
related to katuk leaves in lowering blood sugar levels. Therefore, this study aimed to determine the
hypoglycemic effect of katuk leaf extract using a glucose tolerance test and collect current data on
plant extracts that have the potential as antidiabetic. In the glucose tolerance test, mice had fasted,
and the initial glucose level (t0) was measured. The experiment groups were given 100, 200, and
400 mg/kg BW of katuk leaf extract. The control group was given 2.5 mg/kg BW of glibenclamide.
After 30 minutes of samples administration, mice were given 3 g/kg BW of glucose. Blood glucose
levels were measured every 30 minutes until the 180th minute after glucose administration. The
data were analyzed statistically using the SPSS application. The literature review was conducted by
searching the literature with certain keywords and inclusion criteria on the PubMed and
ScienceDirect sites. The blood glucose levels of mice in the katuk leaf extract group at doses of 100,
200, and 400 mg/kg BW were not significantly different from the positive control group. Katuk
leaves extract at doses of 100, 200, and 400 mg/kg BW could not prevent increased blood glucose
levels. From the literature study, 27 journals were obtained, which were then analyzed further. The
Thymus is the genus with the most plant species in the family Lamiaceae, exhibiting an antidiabetic
effect. Methanol was the most widely used solvents in the plant extraction process, with
antidiabetic effects.
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