STUDY OF DRUG INTERACTION POTENCY IN METHADONE MAINTENANCE THERAPY PATIENT AT HASAN SADIKIN GENERAL HOSPITAL BANDUNG

• Main Author: Sally
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/62173
• Institution: Institut Teknologi Bandung

Methadone Maintenance Treatment (MMT) is a program established as a harm reduction of the use of syringes alternately or recklessly among opioid or drug injecting users (IDU). Methadone is a potent synthetic opioid agonist which is well absorbed orally and the effects of methadone are qualitatively similar to morphine and other opioids. Therapeutic efficacy determined by several factors, such as pathological condition of the patient, appropriate dosing of methadone, and interaction between methadone and other drugs consumed by the patient. Objective of this research is to identify drug interaction on patient of methadone maintenance treatment in relation to therapeutic efficacy. This research is a descriptive research and was done retrospectively by collecting data from medical record of active Methadone Maintenance Treatment patients in February 2012 until February 2013 with total patients were 63 persons. 66,67% patient used antiretroviral drug and there were 9 drug classes used by the MMT patients to treat their psychological condition or other diseases. 40,58% patient used benzodiazepine, 28,98% antibiotic, 4,35% antipsychotic, 5,80% proton pump inhibitor, 4,35% analgesic, 2,90% antidepressant tricyclic, 2,90% vitamin, 2,90% Selective Serotonin Reuptake Inhibitor, and 7,24% other classes (antifungal, antivirus, mucolytic agent, and corticosteroid). This research showed there were 43 drug interaction incidences among MMT patient with each type of interactions were mayor 9,30%, moderate 65,12%, and minor 25,58%. According to the result of this research, there still were drug interactions among methadone maintenance treatment’s patient and less supervision about drug used by the patients. Active pharmaceutical care and counseling are needed to prevent and reduce drug use that potential to interact between methadone and other drugs.